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KMID : 0359319870270020269
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Korean Journal of Veterinary Research
1987 Volume.27 No. 2 p.269 ~ p.275
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Late Biological Effect of High - dose Radiation in the Mice
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김성호/Kim, Sung Ho
김영주/윤택구/오영란/Kim, Young Ju/Yun, Taik Koo/Oh, Yeong Ran
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Abstract
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Radiation-induced life shortening, carcinogenesis and other pathological changes were investigated in NIH(GP) mice after ＾(60)Co-γray irradiation (100∼700rads).
The results were summarized as follows :
1. There were little difference in body weights, hematological examination and other clinical findings between normal and irradiated groups.
2. Mean survival time of the mice after irradiation were decreased dose-dependently.
3. Main gross findings of the mice irradiated were appeared as enlargement of spleen, thymus and lymph nodes, tumorous nodules of lung and cyst of ovary. Especially, enlargement of thymus was promineort in high dose group.
4. Microscopically, there were various findings including myeloid leukemia, thymic lymphoma, lung adenoma, adenosquamous cell carcinoma of pancreas, pneumonia and other pathological changes. Especially thymic lymphoma was highly frequent in the 700 rads group.
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KEYWORD
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